Dual Power: RNA-seq + RNA Modifications

Capture the complete transcriptomic profile while identifying m6A and inosine modifications in the same experiment.

Low Input, High Sensitivity

Profile scarce samples such as biopsies with as little as 20 ng poly(A)-enriched RNA or 250 ng total RNA.

Single-Tube, One-Day Workflow

Go from RNA to sequencing-ready libraries in a single-tube format in 7 hours with just 3 hours of hands-on time.

Quantitative & Reproducible

Proprietary spike-in controls and machine learning-based peak calling ensure robust relative quantification across replicates.

Companion Analysis Pipeline

EpiScout analysis software delivers ready-to-use RNA modification maps, gene expression counts, and intuitive reports.

Enrich & Encode
RNA fragments carrying m6A or inosine are selectively enriched using engineered binders and encoded with modification-specific barcodes.

Dual Libraries
90% of RNA undergoes enrichment, while 10% is processed as an unenriched solution control—providing a matched RNA-seq baseline.

Library Preparation
Both fractions move through the same streamlined workflow, generating sequencing-ready libraries in a single day.

Data Made Simple
Upload FASTQ files into EpiScout analysis pipeline for automated alignment, deduplication, peak calling, and differential analysis.

Turnkey Solution

End-to-end data delivery

We handle the complete workflow from RNA extraction, library prep through sequencing and analysis. Results are returned as an interactive EpiScout HTML report with downloadable BAM, BED, FASTQ, vcf, tsv, files, and publication-ready figures.

Low RNA Input

High performance with a broad RNA input range

Tissue biopsies often contain less than 500 ng of total RNA, challenging many RNA sequencing methods. With the EpiPlex Duo-Mod Service, you can obtain exceptional data quality with as little as 20 ng poly(A)-selected RNA or 250 ng total RNA.