Share this post on LinkedInIn this insightful interview, Byron Purse (Alida Biosciences co-founder) and Pete Dedon (MIT) dive into the growing impact of RNA modifications on translational research.
Pete shares his journey from studying DNA damage and epigenetics to focusing on epitranscriptomics, highlighting early work on stress-induced tRNA reprogramming and how RNA modifications like m6A, inosine, and pseudouridine selectively control translation.
The discussion also tackles key challenges in detecting modified RNAs from limited samples and underscores the importance of standardization, accuracy, and reproducibility in this rapidly evolving field.
AlidaBio’s EpiPlex™ platform makes studying RNA modifications accessible, offering both kit and turnkey services, including the EpiPlex™ Duo-Mod™ (m6A + inosine) and EpiPlex™ Tri-Mod™ (m6A + inosine + pseudouridine) services, with high sensitivity from as little as 20 ng of mRNA.
Explore additional posts in our Mods in Motion series
Blog posts
What Are Those RNA Modifications Doing for Gene Regulation?
The hidden language of RNA – how epigenetics is shaping medicine