Mods in Motion
Your guide to the epitranscriptome
Podcasts and Videos
EpiPlex™ Technology in Action
September 24, 2025
Video of AlidaBio’s EpiPlex Platform workflow, showing step-by-step process from RNA sample preparation to sequencing-ready library creation and analysis in the EpiScout software. Visual highlights include enrichment-based library prep using non-antibody binders, streamlined protocol steps, and data output displaying detection and quantitation of RNA modifications (m6A and inosine) alongside gene expression.
The EpiPlex™ Platform for Multi-Target Detection of RNA Modifications
August 5, 2025
Dr. Gudrun Stengel, CEO and co-founder of Alida Biosciences, introduces the role of RNA modifications in gene regulation and their emerging importance across biology. She also presents the EpiPlex™ Platform—a novel technology that combines engineered molecular recognition and proximity barcoding for transcriptome-wide, multi-target detection and quantification of RNA modifications.
What Are Those RNA Modifications Doing for Gene Regulation?
June 18, 2025
In this episode of the cc: Life Science Podcast series, Chris Conner speaks with AlidaBio CEO and co-founder Dr. Gudrun Stengel about the emerging science of RNA modifications, chemical changes that fine‑tune gene expression. Dr. Stengel discusses how the “hidden code” shapes cell fate decisions and influences disease trajectories. She also explains how AlidaBio’s EpiPlex™ platform is pushing the field forward with robust, sequencing‑based detection of RNA modifications such as m6A, inosine and pseudouridine, bringing new clarity to cancer biology, stem cell research, and even crop engineering.
The hidden language of RNA—how epigenetics is shaping medicine
May 14, 2025
Dr. Gudrun Stengel, CEO and co-founder of Alida Biosciences, shares how her team is unlocking the biology of RNA modifications with next-generation epigenetic tools. In this podcast hosted by ThermoFisher Scientific, she explains the science behind AlidaBio’s EpiPlex™ and EpiScout™ platforms. Tune in for insights on startup life, the future of RNA therapeutics, and the promise of multiomic discovery.
Blog Posts
The Power of Inosine: How RNA Editing Shapes the Transcriptome
August 12, 2025
In this post, we explore the chemistry of A-to-I editing, the distinct roles of ADAR1, ADAR2, and ADAR3, and how this dynamic process influences everything from neuronal signaling to viral defense.
From RNA modification sequencing data to biological insight. A case for bioinformatics.
July 16, 2025
As RNA modification research accelerates, standard RNA-seq and CHIP-seq tools are no longer enough. From m6A to inosine, mapping and interpreting these chemical marks demands specialized bioinformatics pipelines. In this post, we explore the unique analytical challenges posed by RNA modification data, highlight best practices, and introduce how AlidaBio’s EpiScout™ platform enables accurate, multi-modification analysis for deeper biological insight.
No Cuts, Just Edits: Therapeutic A-to-I RNA Editing as a Safer Alternative to CRISPR’s Scalpel
July 7, 2025
CRISPR transformed precision medicine by enabling targeted DNA edits, but concerns about long-term safety persist. A-to-I RNA editing presents the possibility of a safer alternative to DNA-targeting approaches like CRISPR, enabling precise, reversible transcript changes without cutting the genome. Explore how this approach might shape the future of therapeutic gene modulation.
Epitruth or Epifiction? How to Know If RNA Modification Data Can Be Trusted
June 4, 2025
In the rapidly growing field of epitranscriptomics, ensuring data accuracy is more important than ever. With new RNA modification methods emerging and sometimes contradicting prior results, how can researchers be confident in their findings?
N6-methyladenosine (m6A): Minor Modification, Major Impact
May 2, 2025
Explore how m6A rewrites RNA’s fate—shaping splicing, translation, and disease in this molecular editor’s expanding story
A Beginner’s Guide to m6A and Other RNA Modifications
April 10, 2025
This beginner’s guide introduces the growing field of RNA modifications, or the epitranscriptome, which adds a dynamic regulatory layer to gene expression.
Epitranscriptomics and Antibodies: A Game of Hide and Seq
March 31, 2025
In this article, we explore RNA immunoprecipitation (RIP), the most widely used and trusted method for RNA modification detection. We will discuss its role in establishing epitranscriptomics as a field, as well as its limitations as the field continues to evolve.